Pat the chicken dry with paper towels. Dry chicken browns better and helps the spices stick.
In a small bowl, mix salt, pepper, garlic powder, onion powder, and smoked paprika. Rub the spice mix evenly over the chicken.
Heat a large skillet over medium-high heat.
Add the oil. When shimmering, add the chicken in a single layer.
Sear for 4–5 minutes per side, until golden and cooked through (165°F internal temperature). If using thick breasts, reduce heat and cover for a few minutes to finish cooking.
Transfer chicken to a cutting board.
Let it rest for 5 minutes, then slice or shred, depending on your preference.
Lower the skillet heat to medium. Add hot sauce and butter. Stir until the butter melts and the sauce is smooth.
For a creamy sauce, whisk in cream cheese until fully blended.
Add the chicken back to the skillet and toss to coat. If the sauce is too thick, add a splash of water. If too thin, simmer 1–2 minutes to reduce.
Taste and adjust.
Add a pinch more salt or a splash of apple cider vinegar/lemon for brightness if needed.
Top with chopped parsley or green onions. Serve with celery, lettuce wraps, or over cauliflower rice. Drizzle with ranch or blue cheese if you like.